Amorepacific has developed an innovative system for evaluating the progression of skin aging and has elucidated the efficacy of its proprietary Ginsenomics™ in slowing this process. The related research findings were published online last month in the Journal of Ginseng Research, an international academic journal. (Paper Title: Compound K suppresses epidermal aging induced by IL-17A treatment and UVB irradiation)
Recent discourse within the gerontology community has increasingly focused on 'inflammaging.' This phenomenon refers to a low-grade, chronic inflammatory state that intensifies with age, wherein elevated levels of inflammatory cytokines (signaling molecules that trigger inflammation) contribute to a decline in bodily functions. Inflammaging exerts a considerable influence on the skin as well; as intradermal inflammation levels rise with age; it leads to structural damage such as collagen depletion and weakening of the skin barrier. This can result in 'accelerated aging,' where the skin ages more rapidly than chronological age would suggest.
Accelerated skin aging is propelled by a complex interplay of intrinsic factors, including inflammation and hormonal shifts, and extrinsic factors like ultraviolet radiation and fine dust. In this groundbreaking study, the Amorepacific R&I Center developed an aging analysis system utilizing the inflammatory cytokine Interleukin-17A (IL-17A) as an intrinsic aging factor and ultraviolet B (UVB) as an extrinsic factor. The research team confirmed that the simultaneous stimulation by IL-17A and UVB significantly amplifies inflammaging phenomena and hastens the aging of the epidermis. In addition, employing this system, the researchers demonstrated that Ginsenomics™—a rare ginseng saponin variant renowned for its potent anti-inflammatory properties—effectively inhibits the production of inflammatory cytokines and normalizes the functions of the epidermis impaired by aging.
Byung-fhy Suh, CTO of Amorepacific R&I Center, remarked, "This study provides significant insights into the mechanisms of skin aging driven by the complex interaction of internal and external factors." He further stated, "It represents a crucial achievement in scientifically substantiating the potential of Ginsenomics™ as a viable agent for modulating the speed of skin aging."
Ginsenomics™ is derived from Compound K, a rare saponin variant found in minuscule quantities in ginseng, which Amorepacific concentrates over 6000-fold using advanced bioconversion technology. Representing the culmination of over five decades of dedicated ginseng research, Ginsenomics™ serves as a signature ingredient in Amorepacific's brand portfolio.